![]() ![]() The majority (94.9%) of patients had an ECOG performance status of 0 or 1. The mean age was 50.2 ± 9.4 years, and 449 (38.1%) patients were premenopausal women. Proceduresįrom Jto March 15, 2017, a total of 1181 patients were enrolled 1179 patients received LBP-based chemotherapy and were included in the safety and full analysis sets ( Figure 1). Human epidermal growth factor receptor 2 (HER2)-positive disease was defined as IHC score 3+, or 2+ with gene amplification by FISH. The molecular subtype of breast cancer was extracted from previous pathological records, or determined using biopsy tissues by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). ![]() ![]() Patients with previous allergies to platinum compounds, coagulation dysfunction, or those who were considered unsuitable by investigators were excluded. Patients with active central nervous system disease or previous resistance to platinum were allowed to be enrolled. Either patients with or without prior treatment with anthracyclines and/or taxanes could be enrolled. The eligible patients were females aged ⩾18 years had histologically confirmed unresectable locally advanced or recurrent/metastatic breast cancer had at least one measurable lesion according to the Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1 had an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2 had a life expectancy ⩾3 months had adequate hematological (absolute neutrophil count ⩾1.5 × 10 9/L, platelet count ⩾100 × 10 9/L, and hemoglobin ⩾90 g/L), hepatic, and renal function had no plans to prepare for pregnancy during the study period and were not breastfeeding. All subjects Allied Health Cardiology & Cardiovascular Medicine Dentistry Emergency Medicine & Critical Care Endocrinology & Metabolism Environmental Science General Medicine Geriatrics Infectious Diseases Medico-legal Neurology Nursing Nutrition Obstetrics & Gynecology Oncology Orthopaedics & Sports Medicine Otolaryngology Palliative Medicine & Chronic Care Pediatrics Pharmacology & Toxicology Psychiatry & Psychology Public Health Pulmonary & Respiratory Medicine Radiology Research Methods & Evaluation Rheumatology Surgery Tropical Medicine Veterinary Medicine Cell Biology Clinical Biochemistry Environmental Science Life Sciences Neuroscience Pharmacology & Toxicology Biomedical Engineering Engineering & Computing Environmental Engineering Materials Science Anthropology & Archaeology Communication & Media Studies Criminology & Criminal Justice Cultural Studies Economics & Development Education Environmental Studies Ethnic Studies Family Studies Gender Studies Geography Gerontology & Aging Group Studies History Information Science Interpersonal Violence Language & Linguistics Law Management & Organization Studies Marketing & Hospitality Music Peace Studies & Conflict Resolution Philosophy Politics & International Relations Psychoanalysis Psychology & Counseling Public Administration Regional Studies Religion Research Methods & Evaluation Science & Society Studies Social Work & Social Policy Sociology Special Education Urban Studies & Planning BROWSE JOURNALSįrom Jto March 15, 2017, patients were enrolled from 34 sites in China. ![]()
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